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I think they mean they're drugs you have to keep taking forever (for the rest of your life) to keep the effects.

Interesting. That usage is the opposite of “forever chemicals” though. Isn’t it a good thing GLP-1s don’t permanently change your body?

It certainly can be a good thing! But it can also be considered a bad thing that you have to keep taking them, and have to keep paying for them forever. A one-time fix (a cure) can be more desirable than a lifelong treatment regimen.

how do you permanently cure obesity? you can try rewiring metabolism with crispr or some epigenetic changes but thats insanely risky, it would be very likely to mess up the immune system and give people cancer or nerve disorders.

maybe i could see something based on modified gut bacteria that produce GLP-1 drugs inside your body. that would run into problems with dose regulation but at least you can flush them out with antibiotics if you get a bad response.

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