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Comment by mettamage | Hacker News Reader

Have any studies been done on this particular psychedelic? I'm curious.

A couple groups are trying to commercialize it. There have been some trials, but they're all relatively limited by depression trial standards. Double-blind is impossible because the participants know 100% if they've received it or not. Someone volunteering to sign up for a depression study to receive psychedelic drugs is probably a believer that they work, so the placebo groups end up disappointed and the active groups are happy they got assigned the psychedelic they signed up.

One of the latest studies: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...

They followed participants for 8 days, which is pretty disappointing. They really need to follow people for several months to see if anything holds or if it's a short-term placebo effect that wears off.

This seems like one of those areas where "double-blind randomized trial" sounds much cleaner on paper than it actually is. If nearly everyone can tell whether they got the drug, expectancy becomes a pretty nasty confound

It's 5-MeO-DMT, better to synthesize it than to exploit the toads for it though.

https://youtu.be/qipKKBmY_LQ

In the DMT world, carts are being sold known as Toad with the 5-MeO-DMT. Lots of very unhappy customers when they are not expecting it.

I wish this was true in the Bay Area. 5-MeO-DMT does not seem to be available and it’s supposedly a unique experience.

Start going to festivals?

You can just order domestic US.

I seriously don't know who would be unhappy about it. Pure 5-meo is a more reliable experience and no endangered toads need to be harmed. I don't know that one would even be able to liquify straight bufo properly to put in a cart for one...also pure 5-meo is maybe 3-5x more potent per weight so that probably makes it all easier too. Anyone pulling the "butttt it's unnaturalllll" card on this one is a fool.

Is anyone even getting it from toads anymore? 20 years ago it was cheap to synthesize and get from the research chemical market along with the 2Cs and friends. I haven’t done any drugs in a decade so I don’t know how hard it is to get now but I doubt an enterprising internet sleuth would have a hard time finding a source.

I read that as they were expecting a “regular” N,N-DMT vape cart but instead are getting 5-MeO-DMT.

https://en.wikipedia.org/wiki/5-MeO-DMT has some references and the "further reading" links might have way more

plenty of scientific and not-really-scientific links available at erowid for 5-meo-dmt

https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml

scientific references specifically at https://www.erowid.org/references/refs.php?S=5meo_dmt

Most recent I know of: https://www.psychiatrictimes.com/view/blp-003-for-treatment-...

Mebufotenin is 5-MeO-DMT

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