Causality is an issue there, I would suggest that genetic auto immune issues that are rather wide spread can cause all of the above. I think people are finding that GLP-1s help with auto immune issues.
I lost 90 pounds and now the heels of my feet are as soft and supple as a baby's bottom.
Being overweight causes all sorts of weird side effects.
As a kid in the 80s, I wondered how it made sense that my diabetic father was told to follow the same model as non-diabetics, which emphasized carbohydrates.
[1] - https://www.theguardian.com/science/2022/dec/09/academy-nutr...
It's all hyperpalatable foods and the effects of extra adipose tissue are know to be bad for pretty much every health metric under the sun.