Basic usage is a no-brainer: write your string, put variables or short expressions in curly braces, add `printf`-style format specifiers after the colon. This is also great because it's a natural extension of `printf`-style format strings.
Of course you can write complicated and confusing f-strings. But then you can write complicated and confusing... anything, really. Many programming languages have extremely weird quirks and cases where basic syntax can be transformed into an unreadable monstrosity, like C syntax for pointers to functions and arrays.
Sure, this increases the language's complexity, but you don't have to use all of it to reap the benefits.