The women aren't the ones detecting they have something wrong with them. They are detecting there is something wrong with the next level up, and shutting down that whole thing. Like an apoptosis gene triggered by excessive misfolded proteins.
It's not just a small number of women.
When the misfolded protein response triggers cell death, the proteins that activate the response are not, themselves, misfolded. https://en.wikipedia.org/wiki/Unfolded_protein_response
no need to start futile fights when you are in the (ideological) minority.