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Comment by Avicebron | Hacker News Reader

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7-OH is the name for derivatives of kratom that contain the active ingredients.

It has opioid-like addiction tendencies.

Lots of people who used kratom to wean themselves off opioids are now addicted to 7-OH. This includes many people over the age of 30.

Evan Edinger (who is 35) was addicted to it (see YouTube link).

It's a not-opioid that just plays with the opiate receptors in your brain and can be purchased in a concentrated form at your nearest gas station in a lot of US States.

Kratom has been around for a while, I remember seeing it in headshops at least a decade ago.

This is different. There’s the plant. Contains about 1.5% mitragynine.

Then there were purified extracts of the active alkaloids in the plant. Started around 30% mitragynine years ago now in the 85% range.

Then there were synthetic derivatives of mitragynine (7oh, mgm-15, etc.). These are much more fun/addictive and surprisingly safe. Almost all “overdoses” involved a mix of alcohol or other drugs. Much safer than fentanyl or traditional opioids because it doesn’t meaningfully trigger respiratory depression leading to asphyxiation. Unfortunately, they’re also addictive. The harm level, imho, was somewhere around alcohol or nicotine.

I used to order it online in like 2005. Crude extracts were available maybe since 2007. The plant almost got banned several years ago. Then over the last few years all these extracts and derivatives have been coming out. MGM-15 is stronger than heroin from what I've heard. Strongest stuff I ever tried was a mitragynine gummy and it felt like hydrocodone. That one gummy had the effects of what I used to get from a couple cups of tea. Good stuff but not risking addiction to try it again. Made me nauseous too

I thought they were talking about krokodil, but nope... I've literally never heard of 7-oh.

yeah, I remember that one, and the bath salts thing. bleh.

Bath salts were synthetic cathinones. Sold online as plant food and bath salts because they were not for human consumption ;) And then they started getting sold in head shops and gas stations. Some are highly addictive, some are more benign. Methylone was a great cheap MDMA alternative and is one of the drugs that Trump signed an executive order to fast track studying for PTSD.

As a guy posting on a nerd message board, you'd probably enjoy the nerdiness of the guys on Bluelight and places like that getting money together to have Chinese labs synthesize the chemicals they theorized would get em high.

Am curious, do you personally feel mdma would be more therapeutic with friends or at a therapy clinic? I find the use of mdma or lsd or shrooms weird in a formalised environment. Some of the stuff makes sense (like drugs used to desensitise people with PTSD to certain triggers (when it doesn't backfire spectacularly; guessing we don't hear as much about that just the not-formalised experiences of it)) to me, but I don't see how it translates for a lot of people (eg, people not in a semi-predictable environment; people in wartime generally either are around bombings or shootings or not, whereas people with other sorts of PTSD have more trust issues; I could see drug use backfiring for almost anyone but the former group. Generally non-complex PTSD responds better, yet it is fairly rare).

Still surprised tv hasn't brought us a show like Breaking Bad but with designer drugs (the newer 21 Jump Street movies don't count).

I might check that site out but more because I like reading case studies about outlying things than any particular interest in drugs. Thanks.

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