Pusher uses WebSockets; this is awesome and a very forward thinking technology however can be limited by older browsers and proxies not supporting the WebSocket connection. Notifyr uses EventSource (also a HTML5 spec) and XMLHttpRequest, aiming to support a majority of browsers, including mobile browsers.
Additionally, we aim to integrate with Apple and Google's push notification system in the future, allowing a universal method for sending push messages with one API for any platform, device or browser.