System-level ACLs; mandatory or discretionary access control; secure-by-default application and network configurations are all for naught if you take an LLM, run it with all the privileges you'd have an accountable, judgemental operator, and then tell it to act based on arbitrary untrusted input which might include prompt injection attacks, something which cannot generally be sanitized.
Well-defined, well-enforced security policies can mitigate disasters, but many in the wild right now just don't account for this kind of threat model.