CAD/CAM software with Cartesian planes are already confusing as is for most folks. Once I started watching some videos discussing tolerances and such from an engineer perspective, the layout, tooling and concepts made a lot more sense to me.
At that point, it's essentially understanding the intention of the tools and if you're performing additive manufacturing or subtractive. A lot of CAD/CAM software is geared toward machine shops and setups and mindsets like that and not necessarily 3D printer-esque communities. I think these solutions are great for the 3D crowd and not so much the engineer.
There are some in-between things that break the mold and do things in unique ways for people who are product designers like Rhino. The node editing in that is so cool. I look forward to seeing what more people can do with AI now and scripting.