What you’d lose is the reply-to forwarding feature.
As far as I can tell, nobody blocks it. Google sometimes rejects emails where the from address doesn't match the real sending address, which is fair.
I guess the first couple of years were rocky, I hadn't figured out DKIM and SPF and all the other blood rituals yet. Back then I got blocked by Steam and banks. But ever since I set up the correct security it's been fine. Been my primary email for a long long time. All my online accounts are tied to it.
Incidentally, I also have free and unlimited aliases. But I don't usually bother because I have a rule to route all messages to unknown addresses into a special folder. I can give out any random address at my domain and it will always make it back to me. So much more convenient than logging into the website to generate an alias.
The biggest issue was if your ip address got listed in a RBL (Realtime Blackhole List), and then nobody would talk to you. Some were easy to get off, others were permanent blocks, and I found those to be constantly interfering with the delivery of mail. At least the rejection would usually tell you which RBL blocked you.
What I really learned during that time is that mail servers have well known IP addresses and reputations. And you can say all you want SPF/DKIM fixes that, but the reality is when google sends your email (even with your custom domain) it gets received.
MX->A->PTR->A->MX
SPF
DKIM
DMARC
mta-sts - DNS and webpage
Also your IPs must be squeaky bum clean, ideally for several years. DNSSEC might help too. In the UK getting as far as DKIM is usually enough (plus clean IPs, even FTTC connections will work if static).> Allowed domains are: gmail.com, hotmail.com, yahoo.com, proton.me, protonmail.com, outlook.com, live.com, icloud.com, yandex.com, tutanota.com, tutamail.com, tuta.io
(I’m not saying we should have been doing that, but the company was in insurance and wanted to be extra extra sure.)
Most of those services (mixi was one in particular I remember doing this) stopped this practice close to 20 years ago though, but some still remain.
I think it was partly due to the "Galapagos phone" era of pre-smartphones, where each carrier used slightly different mobile web standards (think WAP and custom emoji).
Here is a current help page for Mitsubishi UFJ bank that lists approved domains for both desktop and mobile use: https://faq.cr.mufg.jp/mufgcard/detail?id=4402
Here is a user complaining (with screenshot) that the mail magazine for tabelog only supports mobile provider email domains: https://king.mineo.jp/reports/13368
Another recent one is the login page for gravity.place has a dropdown for country codes (for mobile login) with only 6 options.
Weibo, Sina you get "Failed registration (mail not supported)" if you enter non-major provider. In china nearly everyone is using qq, 163, 126, sina. Probably >99%
But I have only had maybe 3 services ever reject my domain, and those were because the domain contains a number.
I have since stopped doing this out of fear that it will actually cause me more headaches with people/systems that don't understand how email works.
What a load of pedantry.
I have never encountered one.
Plenty of providers, but perhaps Apple needs to be forced to open up hide-my-email-providers for others.
Only the EU is capable of doing such thing