The reason B-52s are still around is because they are combat-effective and cost-effective relative to other aircraft, such as the B-1 and B-2 (both of which I also worked on). Whatever replaces the B-52 will have to be something new and something cost-effective. I don't think that currently exists.
The B-1 has only been combat/cost effective in more recent years after an extended rough patch spanning decades -- actually, I'm not even sure it's cost-effective. The B-2 has always been combat-effective, but was never cost-effective to operate or maintain.