Seems like it'll be a hard sell since steam is already so dominant and enterprise is dominated by tailscale... I see the proposal for being able to work with many different networks from different companies at the same time, but it's a pretty rare usecase and nothing some iptables can't solve.
I can see the argument for chat in heavily censored regions of the world, but not sure if there's any advantages that iroh can offer over other solutions.
Market fit will be hard to find, but best of luck.