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While it’s a fairly good sized dose, it’s not one that would typically produce a nightmare trip scenario.

As far as ethics go, I would absolutely sign a document that gives the right for experimentation in the event I become incapacitated to some degree.

5+ grams is considered a "heroic dose", i.e. the one that is needed for ego death and subsequent therapeutic effects.

I wouldn't, or put constraints into it - you may be incapacitated but you may also still be aware, and you wouldn't want to get I-have-no-mouth'd.