But I can't think of a program more worthy of sandboxing when run with untrusted input than ffmpeg. It's a huge amount of C dealing with the most complicated video and audio codecs, which is notoriously impossible to get completely right.
But it's not actually that big of a problem. I run ffmpeg inside a VM or gVisor, and the end result is usually a video file that I'm perfectly willing to play in my browser, where it gets decoded in yet another sandbox because this shit is hard.