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I think it's a useful meme, as long as applied appropriately - where it truthfully promises some sort of surprise and potential insight.

It seems to have originated with Eugene Wigner's 1960 "The Unreasonable Effectiveness of Mathematics in the Natural Sciences".

At some point someone will analyze this pattern and post an article named "The Unreasonable effectiveness of the 'The Unreasonable X of Y' template".

Everything old is new again! We've had "Go To Statement Considered Harmful" Considered Harmful [1].

Now it's the Unreasonable Effectiveness of "The Unreasonable Effectiveness of X".

It seems like "X is All You Need" is All You Need.

All you need is the unreasonable effectiveness of ... Symmetry.

Heh, on my watchlist - ""The Unreasonable Effectiveness of Group Theory" - https://www.youtube.com/watch?v=1XsXRUsNEC4

The Unreasonable Annoyance of Cliches

But then, this thead is all about proteins incorporating structural cliches, isn't it?

This and "How I learned to stop worrying and love ___". I can't identify what grinds my gears so much about it, perhaps it's the laziness.

Competing with "x is all you need"