As I recall, perhaps erroneously, Guild Navigators are nominal humans who owe their ability to move ships to being spiced to their gills.
Via the Navigators, who lived in dense clouds of spice, transport across the Dune universe was possible - spice was as fundamental to trade and commerce as oil has been here on earth for the past century.
If that recollection was correct, it seems odd to overlook one of the key layers of the original work (as I recall it, of course).