"Design me a 3d printable rocket engine for a hobby rocket project. Verify it's design in a full simulation. Iterate until it works reliably in simulation based on a verified printable design on a consumer laser sintering device (or substitute contract manufacture for under 1000 dollars)."
This is a hobby version of a project, but you can imagine commercial versions of the same prompt for new databases, genomics studies, material analysis, operating systems etc.