This is anecdata, but as someone who has used exogenous testosterone for the past 10 years, I feel significantly better with low T + high E2 than high T + low E2.
I've had E2 levels as high as the low end of female ovulatory range (see attached image at bottom) and felt fantastic, though personal response varies.
I stopped using aromatase inhibitors after the first few years due to having a worse sense of wellbeing compared to using none at all.
Now, I typically let my E2 sit around 60-90pg/mL (roughly x2-3 upper end of male reference range), which is where lands on 200mg/wk Testosterone, when doing TRT.