There's (minimal) research on psilocybin doing just that. One of the tragedies of prohibition is that we just weren't able to study these psychedelic compounds easily for 50+ years.
I haven’t used psilocybin in a clinical setting but have gone through an alternative psychedelic-assisted therapy process. Very interesting results and many positives.
Paul Stamets has evangelized psilocybin + lions mane + niacin for years in a microdosing format, but again, the research is lacking largely due to prohibition.