With things like Secureboot, TPM modules and ever increasing demands to lock down systems, there is the risk that even libre software will be snuffed out. While not those technologies explicitly, similar less friendly things may come up in future. And when that happens, being beholden to billion dollar hardware companies won't seem so friendly. A little alarmist, but I didn't think we would be were we are today as it is.
One interesting area is about how to make software that is not hardware locked but easy enough to implement with very little work involved.
This is where projects such as UXN come in. https://100r.co/site/uxn.html
A system spec that is only 32 instructions deep, something that a single person could implement in less than a week. Essentially the hardest part is building the hardware Abstraction Layer. It wouldn't be efficient but it is very portable and thus makes it resilient to any future possible shocks.