House of Leaves is meant to be read with the weird layout and coloring (e.g. the word "house" always in blue)
It's a fun book! I first read it as a kid at my grandparents little condo in Mexico. I read some on the plane there and back, but the most scared I got was when I read one particular scene alone at night in the kitchen when everyone was asleep. I think it's the only time my heart rate has ever truly jumped like that reading a book.