You may have to spend extra work to get things running; but once it's done, it runs forever without a hitch.
I know, I use Slackware. It's regarded as a very technical distribution and some manual configuration is expected but once it's done, it's done. I have configs from > 20 years ago that I still use without a hiccup.
Yeah... no. If you're dealing with changing systems, you'll need continued support from maintainers. And there's a lot of stuff out there in the business world that is commonly used and breaks all the time. Stuff will break. If not, it is not getting updated. In that case I'd be more worried about security than compatibility.
Claws-mail has all my email for over 15 years. My inbox is several gigabytes in size, which claws handles flawlessly. And the software is continuously maintained. I'm using version 4.4.0 now, which was released 16 days ago on March 9.
So... yes.
Uptimes of half a year are not uncommon, the record so far is 400+ days. I just don't shut it down unless there's a serious kernel or hardware upgrade.
It just works, non-kernel updates, stuff being plugged/unplugged, couple times I swapped sata hdds without turning off power (which is simple, they are hotplug by design, just don't drop the screws onto motherboard and don't forget to unmount+detach first).
Now, when I used to and test some cross-builds for windows (win7-win10 era), I had another dedicated windows machine for that. And even though I tried to make it as stable as possible, it was a brittle piece of junk, in comparison.
So in my experience, yes, linux is fundamentally different usage philosophy: you don't need to think about what crap Microsoft will break your workflow with next Tuesday.