We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.
Here is a site you can use too see how most pharmaco therapy is lacking.
https://pain-calculator.com/calculators/osteoarthritis-pain/
Very few painkillers that are not blood thinners. Paracetamol and canabinoids are a couple of rare exceptions.
My uncle broke his hip in his old age. He died shortly after because of the bleeding induced by painkillers.