Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
salk.edu
salk.edu
I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
(You somehow get the full article via https://www.iflscience.com/humans-may-be-causing-cancer-in-o...)
Here is a site you can use too see how most pharmaco therapy is lacking.
https://pain-calculator.com/calculators/osteoarthritis-pain/
Very few painkillers that are not blood thinners. Paracetamol and canabinoids are a couple of rare exceptions.
My uncle broke his hip in his old age. He died shortly after because of the bleeding induced by painkillers.
What all that, how can you defend opiates? Opinion of society is irrelevant here, they are absolute scourge if used enough, and nobody is immune.
i do argue that in the correct harness, opiates could be distributed to minimize unnecessary suffering at least somewhat - not 24/7, because literally any drug will result in tolerance (and debilitating physical side effects, something opiates lack) at that point. our current system is unsatisfactory - people are not taught how to take drugs correctly, and people exist in a system that naturally causes dopamine seeking reward systems to malfunction. while some are born psychologically weak, inherently leading to addiction susceptibility, society is expressly designed to produce such weakness in order to maintain the status quo. of course such an environment is not positively conducive to the dopamine flooding effects of opiates. i dont blame opiates for the system in which they exist.
regarding personality cracks, i still refer to rat park for the most part, saving brain resets such as ibogaine for extreme cases - our addiction inducing society (as a whole, not merely the opinions wherein) does not imply impossibility of rewiring addictions. regardless, some people think cracks are beautiful (ref. kintsugi).
do you argue that everyone should be instead placed on nsaids that destroy the stomach and liver, killing them earlier and objectively adding pain prior? is the current trajectory (that is, entirely depriving the suffering of effective relief, regardless as to their age bracket) for the best?
NSAIDs are known to kill your stomach, your kidney, your liver, and your heart, whereas opiates do not. And they are ineffective for a lot of people's chronic pain, on top of that.
in a few years when non opiates (ones labelled as equivalent to opiates in terms of analgesia) are cheap, opiates will go the way of benzos - only prescribed by old doctors who learned under different guidelines. then chronic pain sufferers will get no pleasure at all, merely blunting. and everyone will be okay with it, the same way they are okay with schizophrenics being blunted by antipsychotics.
I was thinking the same thing. There is no way people who have chronic pain are saying these things. And if you think about it, it is sickening that people who are fine and do not have chronic pain are the ones dismissing a painkiller, or are trying to dictate someone else's life because they heard opiates are bad (opioid crisis, war on drugs).
And yeah, everyone will be okay with it. Sometimes I really wish people were in my shoes... We need more people experiencing it, otherwise we really are f....d (because they lack empathy, it seems). Good comparison to schizophrenia, by the way.
I really hope that you are wrong though. :/
(BTW, any way I could reach out to you?)
ive come to the point where straight up forcing people into church to be told they are selfish 1x a week is probably the best solution. if a secular version could exist id be all ears, frankly i dont care if god is real or not, people dont follow the commandments and society would be better off if everyone did.
i made a reddit account under this handle a little while back, although it was immediately banned. so i couldnt respond, but i could recieve your email address there and reach out myself.
In this case some public reads "smoking a joint daily equals invulnerable to Alzheimer, science says so".
If you make a product you can make a study that shows it has some kind of benefit in some specific way, even if it probably causes more harm in other ways that are less obvious, and then you can sell it. Media will spread around your study especially if it shows something that will be a bit click-baity, and any study or discussion of the possible downsides will get far less attention.
This is also why basically every edible plant has some article saying it's a "super food" etc etc.
[rolls eyes]
lots of anecdotal evidence suggests donnie t like stimulants, esp. the kind that you can put up your nose.
this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content.
the legendary MTF strain regularily trumpets a 25-30% THC content.
now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass.
at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let alone at one sitting, and doing that for 6 days in a row sounds frightening, not recreational.
Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
Similarly, there were other drugs that lowered cholesterol that didn’t show a significant reduction in coronary events. As we later learned, it’s not nearly as simple as “cholesterol bad.”
https://pubmed.ncbi.nlm.nih.gov/41160460/#:~:text=ResultsAt%...
https://www.nebraskamed.com/health/conditions-and-services/n...
But somehow I doubt it will be found to be that effective.
Now that it's legal and everywhere, I just get super fun panic attacks. I'm worthless, I'm failing as a parent, everybody hates me, you know, the normal anxiety attacks. Even Charlotte's Web that's SUPER low THC gives me panic attacks.
It's like my body hates it when I'm happy? I would give anything to be able to fix this problem.
1. I've eaten like crap. Things too heavy I'm grease, processed food, and red meats. When I'm rating cleaner, I don't feel as panicky
2. If I feel the panic coming on, I HAVE to do some sort of aerobic exercise in that first 15 minute "induction" phase of smoking. Otherwise I'll carry the panic along through the entire session.
FWIW, YMMV
5km goes by fast! And orange juice tastes great after.
Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations.
Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase in amount of CBD will create an anxiety causing superdrug.
I experienced it once - on a party in a country where CBD strains are legal to buy by anyone, as long as they contain ~0%THC. And high quality high THC strains can be bought at a pharmacy with a prescription.
A friend rolled a 50%/50% joint, approx 0.5g total, and we proceeded to smoke it whole, just the two of us. I was surprised you could get that high without a shadow of a paranoia.
I never particularly cared for cannabis in general in the past–it didn’t give me panic attacks, but even a little bit made me feel kind of on edge. The 1:1 stuff is dramatically more pleasant.
Maybe it's just getting older? Who knows. I just wish I could get high a couple of times a week so that I sleep more than 2 or 3 hours.
A couple years ago (around 40) I started taking a low dose antidepressant for unrelated reasons and noticed that the weed induced anxiety mostly disappeared. My guess is that for some people there’s a serotonin/anxiety component that THC can amplify, but that’s just speculation on my part.
Not suggesting antidepressants as a solution by themselves. They come with their own tradeoffs and I wouldn’t take them just for that. But it has been a pleasant side effect I didn’t expect.
I feel like that strain is for EXPERTS. You can always mold it to the vibe you are aiming to reach in that present (ofc in the appropriate environments).
Do you feel like the anxiety just the cascaded result of ... "poor planning" over an extended, day-over-day staggering, sleep-deprived, period of time? I consider my self naturally the poorest of poor planners. My brain is just RAM with zero cache that i always imagine that I have. I've had weeks wiz by if I do not get on top of a fun, MJ propagandized base routine / schedule in place.
Apologies! Worse case, this could just be a swing and a miss. Empathies attempted.
Full spectrum hemp (~0%) definitely feels like the answer, here!
Does hemp have the same relaxing qualities?
Terpenes are the secret to cannabis.
Most cannabis has terpenes as a consequence.
Some cannabis has terpenes as a priority. This is the best cannabis.
The “essential oil” of the cannabis plant.
Look for brands with lab tests that include terpene levels, and mycotoxins/solvents, for best results!
Care to explain this? Or what I'm looking for with terpene levels?
My experience buying pot is two things
1. Before it was legal you got whatever bullshit they had.
2. Asking the worker at the dispensary for the lowest possible THC containing strain.
Simply them being on the lab test is a huge green flag for quality/safety.
Most fly-by-night ops and money-grubbers will perform and post the legal minimums (at best).
But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".
If you end up smoking high percentage THC with little to no CBD, those who with tactile brains will enter a state of negativity. Anxiety, paranoia et cetera.
Essentially just roll CBD leaf only with your main THC leaf and this should equal the balance but again this is all anecdotal and myself as experiment.
I hate being truly high, but a weed "buzz" is great for falling asleep, especially when ill (I often suffer more from severe lack of sleep than from any of the other effects of whatever common virus or bacterial infection I manage to catch). It doesn't take much for a lightweight (a status I have carefully maintained) to reach "buzz" territory, and only a little more to reach "properly high" territory (which, again, I find rather unpleasant).
I'd suggest edibles and starting at 2mg, max, for a first attempt, working up 1mg at a time (in a totally different session, on another day!) until desired effect achieved. Like I've been at this a while and a 10mg gummy, which is a common single-gummy dose size in many states, will take me past where I ever want to be. 5ish is about right for me, maybe up to 8 if I need a stronger kick for some reason (like, say, I'm sick and need to get high enough to sleep most of the night despite significant sinus discomfort or throat pain)
FWIW I also doubt the anti-Alzheimer's stuff will pan out, or if it does, it'll be some targeted therapy with specific chemicals, which won't look a lot like any products from a dispensary.
https://news.harvard.edu/gazette/story/2010/03/alzheimers-as...
And also, apparently, the registered trademark?
> The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
Standard disclaimers apply.
Cannabis really needs a lot more study.
Rather frequent use (as in not every day all the day but lets say couple of times a week) can have some decline but IMHO its still temporary. If the brain is already used to lower learning and complex analysis activity then it will be compounded but otherwise it shouldn't. I sometimes fall here, and I integrate internal banking systems for a living for 2+decades in very competitive place plus raising family and have mortgages, so no shortage of stress. Any miniscule decline is more than compensated by relief of stress and some giggly happiness, plus that massive creativity spike which allows me to catch up with stuff slowly sliding out of focus (and then biting hard like bureaucracy, taxes etc). Literally subconsciousness sliding notes underneath the doors of my mind, topics often pop out of blue, in such frequency that I sometimes struggle to keep up and take notes since next one with higher priority comes and then next one.
Full on stoner - thats a goner, if we talk decades of use, I think. YMMV. But - I've met folks who had periods of life where they smoked all the time every day, for 5-10 years, usually teens (where I would say folks are very vulnerable since brain is still evolving). All are fine now in various roles in their lives.
No, it has not improved my memory. Though, I am not really certain anything does. At least, not permanently. Though, I will say the effects on memory are rather complex. Some diminished abilities in some domains, but oddly some enhancements in a select few domains.
I am 'neurodivergent' apparently, so my experiences might not be worth much.
In my defense, it may have been a stupid joke but it's not as stupid as trying to prevent brain damage by taking cannabinoids at levels known to cause brain damage.
Here. Take my upvotes to balance it out a smidge.