for some reason that hasn't happned to me yet. im only in my 50ies, but I have been on a split keyboard for a long time...
If I had been a bit more intelligent at how I was learning, and focused on improving reading skill instead of simply wanting to play whatever music I liked, I would have probably never had problems. Rhythm games in general boil down to training your brain to read moving patterns and convert them to scheduled movements in your body (but mostly your hands). Once you get to an intermediate level you get these "flow states" where you realize you were basically unconscious for most of the song, not a single thought, just internally observing your body's reactions to the screen. Almost a type of meditation.