When the neurons didn't get stimulated by the application, performance did not improve. The only explanation our data science people has is that the neurons began to learn and perform the desired (highly abstracted) task of 'playing Doom'. This was not a surprise as we've shown this before with a version of Pong using a different platform. We built the CL1 and the CL API to enable rapid iteration on this sort of work.
One benefit to this is that when you have a measurable learning effect, you can measure this before and after exposure to an experimental drug or other molecule. It becomes possible to test the impact on neuron function, not just survival.