I believe current official guidance if you want a lot of random data is to use v8, the "user-defined" UUID. The use of v4 is strictly less flexible here.
> To be clear, UUIDv8 is not a replacement for UUIDv4 (Section 5.4) where all 122 extra bits are filled with random data.
> UUIDv8's uniqueness will be implementation specific and MUST NOT be assumed.
Here's a spec compliant UUIDv8 implementation I made that doesn't produce unique IDs: https://github.com/robalexdev/uuidv8-xkcd-221
So, given a spec-compliant UUIDv4 you can assume it is unique, but you'd need out-of-band information to make the same assumption about a UUIDv8.
I wrote much more in a blog post: https://alexsci.com/blog/uuid-oops/