I've recently made a dozen vastly different projects with Typst, ALL of which would have created dependency hell, syntax noise, and hours of extra pointless work in Latex. It's such a clear win at this point it's embarrassing.
(I've done everything in it from write honors theses and format CVs.)
I've been interested in Typst. But beyond report generation (which I avoid in general), I don't really have a general "document processing" tool, but multiple specialized ones, and given Typst's current jack of all trades/master of none status, I'm not sure what it'll replace. I use Quarto for a lot of my statistical computing, LyX if I need to do a lot of finicky math typesetting (e.g. if I need to break out \qquad), and Word - god forbid - for my non-technical collaborators.
If I had to use LaTeX, I'd definitely do it via LyX.