Depends what your niche is. Do you manage a petabyte cluster? All of a sudden, everything that used to be "complexity theory" becomes "complexity practice".
For example, I believe that the problem of creating optimal schedules for high school students is NP-Complete (optimal in the sense that it will satisfy all of the students' preferences for electives, and all of the teachers' preferences for the classes they want to teach).
Yes, I admit that the example will never involve petabytes of data. That doesn't invalidate my original point though.