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Ghidra takes a program and unravels the machine code back into assembly and thus, something resembling C code. Allowing you to change behavior.
Cheat Engine doesn’t modify the binary. Ghidra can.
To clarify for other people who may not be familiar, (though I'm far from an expert on it myself) you can inject/modify asm of a running binary with CE. I'm not sure if there's a way to bake the changes to the exe permanently.