Well, it seems easy enough to test if you think you are getting efficiency 'for free'. Dump a 10GB binary into a SingleFileZ, and see if your browser freezes.
Edit: I've just implemented the "good enough of my machine fix" aka the "easy fix", https://github.com/gildas-lormeau/single-file-core/commit/a0....
Edit #2: I've just understood that "parent" in "this method cannot interrupt its *parent* document's loading" from the MDN doc probably means the "parent" of the frame (when the script is running into it).