Taking favourite novels which are within arm's reach: Sure "Rainbows End" is Science Fiction which doesn't involve space travel etc. but "Incandescence" is also SF but that's deeply about space travel. Banks' "Whit" and "Surface Detail" are both sat here. One of those is set in a lightly fictionalized Scotland and the other is a Science Fiction novel where the main protagonist dies but is resurrected, then is witness to several of the most significant space battles of her era. But like, if you didn't know, how would you guess which is which?
Now, Banks wasn't a hard SF writer. Unlike say Egan's "Incandescence" none of the events of his SF novels are actually physically plausible, but presumably this list is about genre SF and thus includes Banks, Bujold etc.