Actually, I'm one of those people. For over 20 years, I struggled with playing piano because I would have to memorize a different fingering pattern for the major scale in 12 different keys. I knew the mechanical process of it, but it was hard to develop the muscle memory and play songs by ear based on intuition alone. So I was most comfortable playing in C major (white keys only) and using mechanical/electronic transposition.
In the year 2024, I stumbled upon the Janko piano layout ( https://en.wikipedia.org/wiki/Jank%C3%B3_keyboard ), which turns out to be the smallest modification to standard piano that results in an isomorphic keyboard. I kid you not, I was up and running in less than 5 minutes - I just treated the layout as if it was a pattern to learn on standard piano, except that it was the only pattern I ever had to learn. On Janko, I found it much easier to play songs by ear, in any key. I wish I discovered Janko earlier, as standard piano was never a good fit for my brain.
For anyone who is curious to try, here's a software Janko piano keyboard that you can play right in the web browser: https://novayashkola.org/janko/