With all the mouse research, a lab should compile the top 300 interventions, lifestyles, regimens, etc, and apply it to a generation of mice. Give them all the best of the best gene edits, diets, environments, drug regimens, therapies, exercise, enrichment, and everything else. Get one or two broods of pups each year and breed them for healthspan and well-being, and each year, incorporate the latest and greatest research. Any time they need treatment, or surgery, select from the latest best research for that specific illness or injury.
We have decades of superb mouse health optimization research, it should be applied.