Hacker News Reader

HN posts about mouse studies always trigger a bunch of skepticism. I’m a layperson so it’s hard to separate the informed comments from me-too contrarians.

Are there areas of medicine where mouse models have a much higher or lower success rate in human trials?

View on HN

There's two issues, success rate (about 5%) and time ... even if it is successful in humans, it will be 5 to 10 years before it's available (and 20-30 before it's affordable)

This is not being a contrarian, but a realist.

To be fair, this same realist perspective seems to suggest humans would not have been capable of developing a COVID vaccine for 5 to 10 years; yet, they identified the virus and authorized vaccine use within eight months.

Not to diminish the accomplishment of rolling out the Covid vaccine in such a rapid timeframe, but… there was something like 40+ years of research into creating mRNA vaccines that laid the ground work.

> and 20-30 before it's affordable

Not if pharma execs and shareholders have anything to say about that

It has also been tested in cartilage samples from knee replacement surgeries.

Reply on news.ycombinator.com