Javascript was a weird exception, being rigidly the only thing available in the browser for so long and thus the only acceptable "compile target" for anything you want to run in the browser. In general I can't name very many instances of "write in X and compile it to Y", for some Y that isn't something you are forced to use by a platform, being all that successful. (See also assembler itself.) The Javascript world gives a false signal of this being a viable approach to a project; in general it doesn't seem to be.
(Note this is a descriptive claim, not a normative one. I'm not saying this is how it "should" be. It just seems to be the reality. I love people trying to buck the trend but I am a big believer in realizing you are trying to buck a trend, so you can make decisions sensibly.)
I did some reverse engineering of compiled C code back in the day. Back when compilers and CPUs were simpler, and optimizations were fewer, it was relatively straightforward for a human to do. That's no longer true. I suspect an LLM would have difficulty with it as well, plus the non-determinism that would introduce would be likely to be problematic.
The other option is to evolve static python into such a language. Looking forward to the PEP that proposed DSLs in Python.