What underlying issues do you see with someone who takes psychedelics (shrooms, LSD, DMT, etc)?
Psychedelics -> Social rejection
MDMA -> Problems with parents
Weed -> Infantilism
Alcohol -> low IQ
NOTE: they are not absolute (e.g IQ below average), but relative to what would make that particular individual comfortable given the life challenges he deals with at the time.
The despair, though, isn't far off: chronic depression, or dysthymia, is common among alcohlics.