1. What costs does the language actively inject into a program?
2. What optimizations does the language facilitate?
Most of the time, it's sufficient to just think about the first point. C and Rust are faster than Python and Javascript because the dynamic nature of the latter two requires implementations to inject runtime checks all over the place to enable that dynamism. Rust and C simply inject essentially zero active runtime checks, so membership in this club is easy to verify.
The second one is where we get bogged down, because drawing clean conclusions is complicated by the (possibly theoretical) existence of optimizing compilers that can leverage the optimizability inherent to the language, as well as the inherent fragility of such optimizations in practice. This is where we find ourselves saying things like "well Rust could have an advantage over C, since it frequently has more precise and comprehensive aliasing information to pass to the optimizer", though measuring this benefit is nontrivial and it's unclear how well LLVM is thoroughly utilizing this information at present. At the same time, the enormous observed gulf between Rust in release mode (where it's as fast as C) and Rust in debug mode (when it's as slow as Ruby) shows how important this consideration is; Rust would not have achieved C speeds if it did not carefully pick abstractions that were amenable to optimization.