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Which is the key aspect of authoritarianism: power is expressed by stating their opinions -- even, indeed, especially, insincere opinions -- as fact.
Doesn't seem to have worked.
My girlfriend died of cancer. She was 30 years old and we had a toddler. No matter how rational you start, terminal cancer diagnosis throws much rationality out the window.
Doctors who get cancer typically stay level-headed. I wish society talked about death and mortality more often and openly, most people are ill-equiped to face it square on, and yet its the one thing that is truly universal. Humanity needs sex-ed, but for dying.
They do. For example "US army sunk a boat with drug traffickers, killing everyone."
see Banality of evil https://en.wikipedia.org/wiki/Eichmann_in_Jerusalem
I mean, we had that and threw it away; centuries of memento mori in various cultures and religions
It's not when you need it that you start googling around
People who put barriers for assisted suicide (like our politicians in France) are heartless bigots. Or did in other words - assholes.
Per article (and not arguing it's effective for human oncology), there are also studies with mice showing effectiveness.
Ivermectin is pretty safe for people to use regardless of whether or not they have parasites, so sure, do the human RCTs. Maybe we'll get lucky and have another tool in our anti-cancer toolbox.
But trying to extrapolate out that it's reasonable for people to take it for cancer based on the current evidence is premature, at best.
>layperson to worry about, either.
We're not talking about laypeople without money nor access to pursue. Adams had money, access, and desperation.
Society would love to put this to bed, but pharma typically avoids funding RCTs for out-of-patent/cheap drugs so we may never get the answer.
You didn't know that?
But over 90% of drugs that show promise in rodents flunk out in human trials.
Something working in rodents is an indicator that it might be worth doing testing to see if it works and is safe for humans. But if you bet against it panning out, you'd still be right the overwhelming majority of the time.
The only thing you can project from rodent trial success is that it is worth continuing to study. It should not guide any human usage at that point.
I now understand you were being sensational with your prior language:
> Projecting human outcomes from rodent studies is 100% quackery
90-95% of them don't pan out! And that's of the ones that progress from rodent studies to human trials. The actual number is even higher, but more difficult to track.
Surely you can see how it would be absurd to extrapolate success from something with, at best, a 5-10% chance of panning out? And panning out as in being approved - lots of things that are approved have less than 100% success rate, particularly in this area.
Was the population being studied one where parasite infections that ivermectin can take care of are endemic?
Yes - improves outcomes in this population because many of them are likely to have parasites and killing them reduces strain on the body and frees up immune system resources to deal with covid
No - you'll find glaring flaws even in a quick once-over.
Hasn't failed me yet.
a) Ivermectin in the best hospital in the capital city of one of our most poor provinces in Argentina
b) The average in the same poor province
I don't expect too many problems with parasites there. They implicitly decided that the difference was ivermectin, not that the hospital is probably x10 better than the average of the province.
Doble blind randomized controlled group or it didn't happen.
From figure 1:
> Complete tumor regression was observed in 6/15 mice on the combination treatment, 1/20 on ivermectin alone, 1/10 on anti-PD1 antibody alone, and 0/25 on no treatment.
Ok, that looks interesting.
As I mentioned above (another comment), pharma tends to avoid developing applications for generic/cheap drugs so we may not see more research on this front. Who knows.
If there is a x5 improvement they will get a method to package both drugs together and sell them for x10 the price. You surely want a profesional mix in the high tech lab instead of a random guy mixing tubes in the back room. Another trick is to add something to the molecule like a methyl -CH3, show that the new version is 10% even better and charge x20 for it.
So my guess is that there is some problem to use this mix, but as I said I can't find any obvious error and it's really interesting. I'd love to read a better analysis from someone that is an expert in the area.
Being “aware of both sides” means engaging evidence and counterarguments in good faith. Repeatedly dismissing data and framing entire groups as inherently hostile is not that. Calling this out is not echo chamber behavior, it is a substantive judgment based on what was actually said, not on ideological disagreement.
Dilbert was brilliant. Adams' political discourse after that became his primary schtick was quite frequently insane.
“When a young male (let’s say 14 to 19) is a danger to himself and others, society gives the supporting family two options: 1. Watch people die. 2. Kill your own son. Those are your only options. I chose #1 and watched my stepson die. I was relieved he took no one else with him.”
“If you think there is a third choice, in which your wisdom and tough love, along with government services, ‘fixes’ that broken young man, you are living in a delusion. There are no other options. You have to either murder your own son or watch him die and maybe kill others.”
That’s surely from the calm rational mind of someone not filled with resentment and hate right?
> After a 2022 mass shooting, Adams opined that society leaves parents of troubled teenage boys with only two options: to either watch people die or murder their own son
https://en.wikipedia.org/wiki/Scott_Adams
Maybe “insanity” is strong but I do not think anyone who holds beliefs like those is thinking straight. Toying with Holocaust denial is not simply “having different opinions to you”.
[citation needed]
Here are my own citations:
https://rationalwiki.org/wiki/Scott_Adams
"In a 2006 blog post (which has since been deleted), Adams flirted with Holocaust denialism, questioning whether estimates of the number of people killed during the Holocaust are reliable [...] If he actually wanted to know where the figures come from, he could have looked on Wikipedia or used his Internet skills to Google it or even asked an expert as he once recommended"
"Just 3 hours after the 2019 Gilroy Garlic festival mass shooting, Adams attempted to profit off of it by trying to sign up witnesses for a cryptocurrency-based app that he co-founded called Whenhub.[58][59][60]"
"After being yanked from newspapers due to racism, Adams moved his operations to a subscription service on Locals. While Adams continued to create a "spicier" version of Dilbert "reborn" on that site, Adams' focus shifted towards "political content". His Locals subscription included several livestreams with "lots of politics" as well as a comic called Robots Reading News, with a little bit of alleged self-help media content as well.[73] His Twitter feed also increasingly focused on angry MAGA politics.[74]"
"Adams continued to believe Donald Trump's Big Lie and maintained that the 2020 U.S. presidential election was rigged. In March 2024, when Adams falsely suggested that US "election systems are not fully auditable and lots of stuff goes 'missing' the day after the election", the Republican Recorder of Maricopa County Stephen Richer explained that US elections actually were fully auditable, and gave some information on the actual process officials use for auditing elections.[82]"
And there's no lack of empathy in immediately discussing the legacy of a public figure, on a site far away from anyone that's personally affected.