When I'm reading Markdown, I almost don't even see the symbols. Beginning a statement with a # immediately just looks like a heading, surrounding a word with asterisks looks italic to me, wrapping a string with backticks looks like code formatting to me, and my assumptions are generally right so I don't need to render very often (which is why the Pandoc -> LaTeX -> PDF pipeline didn't bother me that much).
If I'm writing LaTeX or something, I generally have a very rough idea of what something will look like, but it's not terribly reliable for me. I need to render frequently because my assumptions about how something is going to look is likely to be wrong.
I mostly use Typst now because it is similar enough to Markdown, and the compilation time is so categorically faster that I see little reason not to use it, but I still respect the hell out of Markdown for popularizing this kind of syntax.