Obligatory reminder that this pill is much less effective than Zepbound, not to mention reta.
HN Search: orforglipron - https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu...
I'm definitely willing to keep taking it. If insurance won't pay for it, I could pay for the pill out of pocket if I had to, which would be cost prohibitive for the injections.
At $300/month cash pay through https://lilly.com, I find the ROI to be exceptional.
My goal is to drop fat, gain muscle, and be strong with good cardio performance, and a GLP-1 turns off the part of my brain that made me carry excess unhealthy fat and eat the foods that made that fat. GLP-1s also promote thermogenesis, so it is turning on the switch to tell your body to burn fat that you would have to fast or get into ketosis via a ketogenic diet otherwise to get into (by first depleting your glycogen reserves). I do not get any fatigue such that I would when fasting or on a keto diet needed to encourage thermogenesis and burning up fat reserves, which is awesome imho.
My brain says "you are fine" instead "you must eat, feel hungry, and get hangry, even though you already have all of this fat." A bug has been patched.
https://pubmed.ncbi.nlm.nih.gov/?term=glp-1+thermogenesis
(think like a hacker, the body is just another system to hack)
Impossible to characterize without height.
https://www.nutrition.gov/topics/healthy-living-and-weight/s...
"A reasonable rate of weight loss is 1 to 2 pounds per week."
Going too fast has downsides.
https://health.clevelandclinic.org/risks-of-losing-weight-to...
Was this plan made with your doctor?
Several GLP-1 pills are in the pipeline, and there is near bottomless R&D budgets being spent on the area currently, but it isn't here yet and this isn't "it."
I'd strongly suggest people ignore this release, and keep using injectable Semaglutide/Tirzepatide.
It could be an anxiety. I developed one after a nasty blood draw. When someone pointed out it was an anxiety response, it sort of just went away.
A total of 205 participants were randomly assigned to receive oral semaglutide, and 102 to receive placebo. The estimated mean change in body weight from baseline to week 64 was -13.6% in the oral semaglutide group and -2.2% in the placebo group (estimated difference, -11.4 percentage points; 95% confidence interval, -13.9 to -9.0; P<0.001).
At what would be $10/day – why's that ineffective?
Plenty of people can’t or won’t inject. And plenty of people don’t need 2.4mg injected.
The pill is cheaper to make, distribute and take. That seems to make economic sense to me.
Source?
As I said above, this is being worked on (inc. by Novo Nordisk), but oral Semaglutide is a very naive early attempt. They got first to market, but that doesn't mean it makes sense for people who can handle injections; you cannot compare doses 1:1 because of how weak oral is, you need to compare action-of-effect. Once you look at effectiveness, oral costs more than injection.
Sounds not ineffective.
> oral costs more than injection
Are these being marketed to the same populations?
You're correct that the amino acid with the sequence YA¹QGTFTSDYSIL²LDKK⁴AQA¹AFIEYLLEGGPSSGAPPPS³ is being manufactured and sold. And people are justified in being wary whether the substance they get is actually a pure version of retatrutide. But it's not counterfeit.
It's an important distinction. Counterfeiters are by definition liars, and it's reasonable to assume that liars are cutting corners. But someone correctly manufacturing a specific amino acid is truthfully selling what they claim to be selling. It might turn out that retatrutide causes you to grow extra eyes in five years, and the FDA trials are on the brink of discovering as much, in which case Eli Lilly-branded retatrutide will never come into existence. For that reason it would be prudent to wait for FDA approval.
So maybe I'm grammatically and formally incorrect. But a lot of this feels very scammy.