In fact, today’s graphic possibilities and available monitor resolutions make it possible to accurately and aesthetically simulate an analog CRT monitor with its scanlines and aspect correction (DOSBox Staging). But of course you can just use big sharp pixels.
What I also like in this project is that they also share logs with what they worked on each game, eg for the resident evil series [0]
[0] https://www.gog.com/blog/resident-evil-1-2-3/#:~:text=RESIDE...
Now I'm wondering if you could put e.g. a Windows virus into a Gameboy game, such that if someone did the opposite of what we're talking about and ran it "natively" then they'd be infected. Afaik this kind of native execution as an alternative to emulation is being done via recompilation projects - see e.g.
NES - https://andrewkelley.me/post/jamulator.html
N64 - https://deepwiki.com/Zelda64Recomp/Zelda64Recomp/3.1-recompi...