Not my first rodeo, Wine is brilliant, especially recently with Valve's support for gaming (albeit hindered by games with incompatible anti-cheat), but it's not a one-size fits all solution.

You're going to struggle running professional apps on it. You might be able to scrape-by. There might be open-source alternatives (rarely as suitable).

Something always ends up bringing me back.

The only thing I haven't tried is the whole GPU-passthrough VM solution which seems the best, but then you need a nice rig and a decent amount of dough.