I've made a similar transformation, going from 233LBS to 160LBS.
http://blog.raamdev.com/2004/03/07/changed-for-life
After losing the weight and getting in shape, my asthma and allergies disappeared, along with my eczema. Fitness has become one of the most important things in my life.
If there is one piece of advice I can give to anyone looking to get in shape it would be this: Stick with it and stay consistent. Fitness is a lifestyle, not a goal or destination (that's why diets fail).