There are calculators with CAS programs that can symbolically differentiate and integrate expressions or even solve certain classes of ODEs/PDEs
In 1988 my Calc 1&2 classes were partially taught using Maple on an MTS mainframe. It did NOT make any of it easier.
The TI-89 came out in 1998 and can do a lot of calculus work. It can go very far in entry level calculus courses and can be very useful for checking work even in the higher courses.