the only thing that might stand in the way is a dependence on reproducibility, but it seems like a weak argument: We already have a long history of people trying to push build reproducibility, and for better or worse they never got traction.
same story with LTO and PGO: I can't think of anyone other than browser and compiler people who are using either (and even they took a long time before they started using them). judged to be more effort than its worth i guess.