I totally get that people are not mice, however animals studies have been useful for all sorts of diseases. Are they really uniquely bad for Alzheimer's?
To put it simply, mice don't get Alzheimer's. We're not studying mice with Alzheimer's, we're studying mice with an mutation chosen for resembling Alzheimer's. But we don't know whether this model replicates the actual mechanisms of the disease, or if it's superficial.
Thanks for the explanation, this really clears up the concerns here. It's easy to imagine scientists attempting to model in in mice and making real progress, but it's also easy to imagine us misunderstanding the real disease well enough such that what we've modeled in mice does not produce real results.
No. I believe the problem is with our artificial models of Alzheimer’s in mice.