> Companies are global, businesses are 24/7
Only a few companies are global, so only a few of them should optimize for those kind of workload. However maybe every startup in SV must aim to becoming global, so probably that's what most of them must optimize for, even the ones that eventually fail to get traction.
24/7 is different because even the customers of local companies, even B2B ones, mighty feel like doing some work at midnight once in a while. They'll be disappointed to find the server down.