I can't think what the issue would be aside from range. One thing that stood out to me about the cybertruck is that they made huge tradeoffs to make it more aerodynamic. The only reason to do that is to increase maximum driving distance. Put a big blocky trailer behind it and suddenly the battery's maximum distance is competing with a gas tank on a much more even playing field. Regenerative braking would make up for some of that in very hilly terrain, but on level ground it just can't get out to as many of the remote areas people take their trucks to.

I really think the first obvious use case (aside from bugout vehicles) would be something like the early road rangers - driving all over a farm and bringing back crates of produce from muddy fields without getting stuck or needing a lot of maintenance.