A notable edge case here is that if EVERYTHING (e.g. market data AND orders) goes through the sequencer then you can, essentially, Denial of Service to key parts of the trading flow.
e.g. one of the first exchanges to switch to a sequencer model was famous for having big market data bursts and then huge order entry delays b/c each order got stuck in the sequencer queue. In other words, the queue would be 99.99% market data with orders sprinkled in randomly.